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Ruxolitinib, a JAK1/2 tyrosine kinase inhibitor approved for myelofibrosis, reverses GPX4 downregulation in TBI and mitigates neurodegeneration, cerebral edema, motor deficits, memory impairment, and anxiety-like behaviors (231)

The heart rate signal with retatrutide, while generally modest, warrants caution in individuals with pre-existing heart conditions, arrhythmias, or those taking heart rate-affecting medications